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Ponce de Leon got mortally wounded in his second expedition to Florida
Source: Early History of the Creek Indians and Their Neighbors #121
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In 1521 he undertook a second expedition, coasting the western side of the peninsula and making a landing, perhaps in Apalachee Bay, as suggested by Harrisse.1 Here, however, he was defeated by the Indians and badly wounded. He returned to Cuba to be cured, but soon died. (Swanton)
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